Clever concept

The SpinChem® rotating bed reactor (RBR) maximizes the convective mass transfer to the solid phase by generating a circulating flow. As the RBR spins, solution is repeatedly passed through the packed bed inside the RBR by centrifugal force. As every liquid parcel makes multiple passages through the RBR, the reaction rates are increased, and the solid phase utilization maximized.

Boosted reaction rates

Real-time video comparing neutralization speed between a SpinChem® RBR and a stirred tank reactor (STR). The video reveals the gentle and efficient mass transfer conducted by the RBR. The results were a 30% faster ion-exchange neutralization of the base, as well as a completely clear solution without any particles.

Remarkable mass transfer

Video showing the efficient phase-transfer between emulsified immiscible liquids and an ion exchange resin when using a SpinChem® RBR. Fine emulsion droplets were created, resulting in effective phase-transfer between the two liquids and the solid phase.



Prolonged solid phase lifespan

When using a SpinChem® RBR, the solid phase is protected within the rotating cylinder. This means that even fragile materials, such as molecular sieves, polymer beads and alginate particles are protected from grinding. The picture shows levels of grinding of molecular sieves using a stirred tank reactor and an RBR, respectively.

No filtration steps

With the resin retained inside the SpinChem® RBR, there are no solid phase particles or solid phase debris suspended freely in the solution. This means that when using the RBR, filtration steps are completely cut out from the workflow. Furthermore, washing, storing and exchanging the solid phase particles are made very quick and simple.

Maintained enzyme activity

Immobilized enzyme activity is preserved through consecutive batches when using the SpinChem® RBR. When comparing the enzyme activity between reactions using an RBR and a conventional STR, the RBR contributes to maintaining significantly higher activity over multiple runs. Data on next slide from biocatalyzed amidation.


Cascade reactions and multistep synthesis

Video illustrating the possibility of performing cascade reactions using a SpinChem® RBR. Red and blue dyes with different chemical properties can be selectively extracted onto different adsorbents within the same run. The dyes were separated based on ionic and hydrophobic interactions, respectively.

Seamless scalability

The generic design of the SpinChem® RBR enables seamless scalability, which means that the RBR technique can be used to process liquids in the range of just a few millilitres, to several hundred cubic metres.

Benchtop screening

The SpinChem® MagRBR is designed for parallel laboratory development and reaction screening in 5-100 mL volumes. The MagRBR is delivered pre-packed with a wide variety of catalyst and adsorbent resins for lipase biocatalysis and enzyme immobilization screening.

Laboratory experiments

SpinChem offers complete laboratory set-ups for running heterogeneous reactions, including reaction vessel, laboratory stand and overhead stirrer motor. The SpinChem® RBR S2, RBR S3 and RBR S3+ together cover liquid phase volumes of 100-3000 mL.

Large-scale processing

Due to the generic design of the SpinChem® RBR, the technique can be scaled up to any reactor volume. If the existing set-up makes it impractical to use the RBR in-tank for batch processing, SpinChem offers other solutions, such as flow systems, where the RBR is used in a separate vessel connected to the main tank.

Mass transfer revolutionized

Learn more on how SpinChem® RBR can eliminate poor mass transfer in heterogeneous reactions during chemical synthesis and biotransformat­ions. See examples of how to preserve activity and facilitate recycling of solid phases in actual applications.