Applications with keyword: Seamless scaleup

Application 1026

Accelerated video showing the removal of methylene blue from 50 L volume of liquid, by adsorption onto activated carbon in a production scale rotating bed reactor (RBR). The decolouration process removed 99.96% of the dye within 10 minutes with a logarithmic decline of concentration as documented by analysis of withdrawn samples.

Products: SpinChem® RBR S5
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    Conditions: Adsorption of methylene blue (20 g, 400 mg/L) onto activated carbon (7 L, 20-50 mesh) placed in a SpinChem® S511 rotating bed reactor (RBR) operated at 200 rpm within a 38 cm diameter cylindrical reaction vessel containing 50 L water and equipped with three baffles placed along the edges. Samples were withdrawn every half minute and analysed by light adsorption without any need for filtration. The video is shown at 20x speed.

Application 1023

Poster describing the screening of resins with immobilized enzymes for esterification reactions. The screening was performed with prepacked cartridges inside a SpinChem® rotating bed reactor (RBR) and compared to parallel screening with prototype disposable magnetic RBR (MagRBR) in 10 mL volume. Both approaches were very quick, required minimum preparation and no filtration. Up-scaled processes enabled quick enzyme recycling, opening for the possibility of semi-continuous processes with attractive production economy.

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    Conditions: This poster contains data from several reactions with immobilized enzymes performed at different conditions. The details of each reaction are displayed under each figure in the poster. This poster was presented at BioTrans2017 - the 13th international symposium on biocatalysis and biotransformations, in Budapest, Hungary, the 9th to 13th of July, 2017.

Application 1021

Video showing how a SpinChem® rotating bed reactor (RBR) for use in 20-300 L vessels was charged with solid particles, used for pH neutralization, drained from reaction liquid and finally emptied from solid phase without opening the RBR. This procedure illustrates one approach to using RBR in production scale equipment without opening the reaction vessel.

Products: SpinChem® RBR S5
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    Conditions: A SpinChem® rotating bed reactor (RBR) S511 was used in a 38 cm diameter cylindrical reaction vessel filled with 60 L water containing phenolphthalein as pH indicator. To this 2 L of ion exchange beads (IRN 99 H+, about 500 µm particle size) were added, followed by 0.5 L NaOH (1 M). During loading and reaction the RBR was spinning at 200 rpm, whereas 50 rpm was used during draining and unloading. The RBR was emptied by spraying water from nozzles in three baffles installed within the reaction vessel.

Application 1018

Capable of processing at least 100 litres of reaction liquid while holding nearly eight litres of solid phase, this rotating bed reactor (RBR) is designed for highly efficient production within your existing plant equipment. These photos show the latest version delivered to customers performing biocatalysis for production of chemicals. Please contact SpinChem® for more information.

Products: SpinChem® RBR S5
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    Manufactured in 316L stainless steel with a stainless steel mesh and having a calculated internal volume of 7.8 litres. Outer dimensions, excluding shaft holder, are 254 mm in diameter and 184 mm in height.

Application 1016

Video showing how a SpinChem® rotating bed reactor (RBR) was charged with solid particles, followed by draining and replacing the reaction liquid without escape of solids. Lastly, the solid phase was removed without opening the RBR. This procedure illustrates a concept for automatic handling of solid phases in production scale equipment without opening the reaction vessel.

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    Conditions: A SpinChem® rotating bed reactor (RBR) S221 within a SpinChem® flower-baffled reaction vessel V221 filled with 150 mL water and 15 mL ion exchange beads (IRN 99 H+, about 500 µm particle size). This 1 min video was edited down from a 2 min real-time process.

Application 1015

Time lapse video demonstrating a prototype vehicle capable of processing two cubic metres of coloured water within five minutes. The raft was carrying two rotating bed reactors that neutralized the basic surface water in a square pond by ion exchange.

Products: SpinChem® RBR S4
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    Conditions: A pond containing tap water (2000 L), sodium hydroxide (150 mL, 1 M), and phenolphthalein (0.8 g) was neutralized within five minutes by two prototype rotating bed reactors, containing a total of 960 mL IRN99 H+ ion exchange resin, attached to a remote controlled floating prototype vehicle maneuvered across the water surface. The project was a cooperation between SpinChem, Umeå University and MTC centre for environmental technology.

Application 1013

Short video of a coloured dye front moving in a transparent liquid through a pipe connecting an external rotating bed reactor to a larger vessel. The total convective flow rate was calculated to 440 L/h based on linear progression of the dye and assuming steady state turbulent conditions at Reynolds number 7900.

Products: SpinChem® RBR S2
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    Conditions: A water filled (2 L) connected system consisting of a tank (1 L) to which an external flower baffled vessel (200 mL) was connected via pipes (24.6 mm ID). A SpinChem® rotating bed reactor (RBR) S221 filled with activated carbon (28 mL, 20-50 mesh) was placed in the external vessel and started rotating at 1000 rpm. Maximum velocity (Umax) in the middle of the bottom horizontal pipe was measured by following the movement of methylene blue (1 mL, 40 mg) by means of counting video frames, yielding a linear flow of 0.32 m/s. From the linear flow rate and the kinematic viscosity of water at 20 °C, Reynolds number in the pipe was calculated to 7900, indicating a predominantly turbulent flow for which the velocity profile is represented by U=Umax(1-r/R)1/7, where R is the pipe radius and r is the position from the centre. Numerical integration of this expression over the cross section of the pipe using the quadrature package in SciPy yielded the determined total flow rate. Note that this is an conservative estimate assuming steady state turbulent conditions which might not yet have established shortly after turning on the overhead stirrer. References: Flud mechanics and transfer processes, J.M. Kay, R.M. Nedderman, Cambridge University Press, Cambridge, 1985.

Application 1012

Time lapse video illustrating how an externally connected rotating bed reactor (RBR) can pump and process large liquid volumes by the convective flow created by the spinning RBR. The concept enables handling of volumes at least 10-100 times larger than the external vessel, thus facilitating installation of RBR technology into existing plant equipment.

Products: SpinChem® RBR S2
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    Conditions: A water filled (2 L) connected system consisting of a tank (1 L) to which an external flower baffled vessel (200 mL) was connected via pipes (24.6 mm ID). A SpinChem® rotating bed reactor (RBR) S221 filled with activated carbon (28 mL, 20-50 mesh) was placed in the external vessel and rotated at 1000 rpm adsorbing dissolved methylene blue (40 mg) within 14 minutes.

Application 1007

Video showing the principle of an automated rotating bed reactor system capable of filling a solution, neutralizing it by ion exchange and draining it. By microcomputer control, unattended semi-continuous batch processing was accomplished for many cycles until the ion exchanger was completely saturated.

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    Conditions: Neutralization of about 500 mL water with 0.63 mM NaOH and 110 mg/L phenolphthalein within a SpinChem® S311 flower-baffled reaction vessel, using a SpinChem® RBR S311 containing 50 mL Amberlite IRN99 at 500 rpm. The automated sequence included filling to level sensor, starting the overhead stirrer motor, stopping stirrer motor when absorbance probe recorded a clear solution, opening the bottom valve until vessel was empty and finally closing the bottom valve to get ready for a new cycle. The entire sequence was controlled by a microcomputer allowing a preset number of cycles to be executed without manual interaction.

Application brochure

Brochure with SpinChem® rotating bed reactors (RBR) – applications, products and technology. Learn from examples how to increase speed and convenience for heterogeneous reactions in laboratory development and production scale. Read about the capabilities and handling benefits with pre-packed cartridges.