Applications with keyword: Synthesis
Epoxidation reactions with in-situ formed percarboxylic acids were enhanced by heterogeneous catalysis and optimized with respect to product yield. The authors concluded that “SpinChem RBR, was beneficial, in terms of eliminating mass transfer limitations, it enabled a simpler collection and recycling of the catalyst and minimized mechanical wear of the solid catalyst”.
Adriana Freites Aguilera, Pasi Tolvanen, Shuyana Heredia, Marta González Muñoz, Tina Samson, Adrien Oger, Antoine Verove, Kari Eränen, Sebastien Leveneur, Jyri-Pekka Mikkola, Tapio Salmi
Industrial & Engineering Chemistry Research, 57 (2018) 3876-3886
Convenient transfer hydrogenation catalysed by palladium-containing beads was performed using a SpinChem® rotating bed reactor (RBR). The set-up resulted in high product conversions throughout more than 10 consecutive batches without any need for filtration to recycle the catalyst.
Photos showing how grinding caused by stirring of molecular sieves can be completely avoided by using a rotating bed reactor (RBR). Molecular sieves contained in a RBR for a 200 mL vessel can theoretically hold 0.23 moles of water. This allows synthesis of product in the range of 100 gram by ester condensation or drying of 25 litres of analytical grade organic solvent.
Conditions: Molecular sieve (3 Å, rods 3-5 mm, 15 g), placed either into a SpinChem® S221 rotating bed reactor (RBR) or free in solution agitated by a 3-blade stainless steel propeller (5 cm), both operated at 500 rpm within a SpinChem® V211 flower-baffled reaction vessel containing isopropanol (130 mL). Photos were taken after 24 hours of operation with the RBR and stirrer in place, respectively. The theoretical calculation assumed an RBR with space for 20 g molecular sieve with a 20% (w/w) water adsorption capacity, a synthesis yield of 99%, a product weight of 450 g/mol, and an organic solvent with a density of 0.8 kg/L and an initial moisture content of 200 ppm; data partly taken from literature; J. Org. Chem. 2010 (75) 8351-8354.
Brochure with SpinChem® rotating bed reactors (RBR) – applications, products and technology. Learn from examples how to increase speed and convenience for heterogeneous reactions in laboratory development and production scale. Read about the capabilities and handling benefits with pre-packed cartridges.
Learn how SpinChem rotating bed reactors (RBR) can eliminate poor mass transfer in heterogeneous reactions during chemical synthesis and biotransformations. Preserve activity and facilitate recycling of solid phases with the RBR. This brochure shows technology and applications.