Results are quite amazing; significantly improved reaction rate, very easy recycling and bullet-proof stability of our enzyme.
Applications
Keywords
- Activated carbon
- Alginate
- Automation
- Behind the scenes
- Biotransformation
- Brochure
- Cleantech
- Continuous flow
- Decolouration
- Easy handling
- Encapsulated cells
- Extraction
- Fast reaction
- Gas-distribution
- Immiscible liquids
- Immobilized enzymes
- Ion exchange
- Molecular sieve
- One-pot multistep
- Organic molecules
- Palladium on carbon
- Polymeric resin
- Preserved activity
- Purification
- Quick recycling
- Rapid screening
- Review
- Scientific literature
- Seamless scaleup
- Simple cleanup
- Simulation
- Synthesis
- Technology
- Viscous solutions
- Water
- Zeolite
Highlighted applications

Accelerated video showing the enhanced adsorption rates of methylene blue onto activated carbon using a rotating bed reactor (RBR) compared to a stirred tank reactor (STR). The RBR decolourized the solution almost twice as fast, did not create any visible fines and required no filtration.
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Conditions: Adsorption of methylene blue (100 mg) onto activated carbon (40 mL, 12-40 mesh) placed either in a SpinChem® S311 rotating bed reactor (RBR) or stirred free in solution agitated by a 5 cm impeller, both operated at 800 rpm within a SpinChem® V311 flower-baffled reaction vessel containing 1000 mL water at room temperature. The video is shown at 12x the normal speed. The solution was decolourized after 5 minutes with the RBR, versus close to 10 minutes with the stirred tank reactor (STR). Samples from the RBR set-up required no filtration, but from the STR all samples required filtration through a 45 µm syringe filter for analysis.

Poster on study of catalyst recycling during esterification and transesterification reactions with immobilized lipases in rotating bed reactors. Data from several laboratories showed that no attrition or grinding occurred and that no filtration was necessary between reaction cycles. The production capacity was estimated to 50 kilograms per gram of catalyst thanks to the high catalyst stability.
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Conditions: This study comprised several different laboratories, immobilized enzymes, and conditions for performing esterification and transesterification reactions using a SpinChem® rotating bed reactor (RBR). The details of every reaction are displayed in connection to each figure on the poster. This poster was displayed at Biocat2016 - the 8th international congress on biocatalysis, at Hamburg University of Technology, Germany, August 28th to September 1st, 2016.

Illustrative video showing how a phenolic colourant is deprotonated and extracted from an organic to an aqueous solvent. Using SpinChem® RBR in a flower-baffled reaction vessel created fine emulsion droplets resulting in effective phase-transfer between the two liquids and the solid phase.
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Conditions: Red 2,6-dichloroindophenol (about 3 mg) in dichloromethane (70 mL) with water (70 mL) converted to its blue phenolate anion using Purolite A500P (25 mL) in OH form (created by treating Cl form with NaOH) packed into a SpinChem® RBR S221 rotating at 500 rpm in a SpinChem® V211 flower-baffled reaction vessel.

Comparison of rotating bed reactor (RBR) technology and fixed bed reactor (FBR) column during activated carbon decolourization. The more efficient use of the adsorbent with a SpinChem® RBR enabled completion of the process within 40% of the time at the same material amount or allowed reduction to 50% material while still being able to finish the process within the same time as the FBR.

Convenient transfer hydrogenation catalysed by palladium-containing beads was performed using a SpinChem® rotating bed reactor (RBR). The set-up resulted in high product conversions throughout more than 10 consecutive batches without any need for filtration to recycle the catalyst.

Brochure with SpinChem® rotating bed reactors (RBR) – applications, products and technology. Learn from examples how to increase speed and convenience for heterogeneous reactions in laboratory development and production scale. Read about the capabilities and handling benefits with pre-packed cartridges.
Application collection
Scientific literature
Whole-cell cascade biotransformations for one-pot multistep organic synthesis
ChemCatChem, 9 (2017) in press
Role of biocatalysis in sustainable chemistry
Chemical Reviews, 117 (2017) in press
Biocatalysis engineering: the big picture
Chemical Society Reviews, 46 (2017) 2678-2691
Reaction engineering of biocatalytic (S)-naproxen synthesis integrating in-line process monitoring by Raman spectroscopy
Reaction Chemistry & Engineering, 2 (2017) 531-540
CFD modeling of flow and ion exchange kinetics in a rotating bed reactor system
Industrial & Engineering Chemistry Research, 56 (2017) 3853-3865
A novel hierarchically structured siliceous packing to boost the performance of rotating bed enzymatic reactors
Chemical Engineering Journal, 315 (2017) 18-24
Recent advances in whole cell biocatalysis techniques bridging from investigative to industrial scale
Current Opinion in Biotechnology, 42 (2016) 169-177
Fibre stress-strain response of high-temperature chemi-thermomechanical pulp treated with switchable ionic liquids
BioResources, 11 (2016) 8570-8588
Catalytic hydrogenation of d-xylose over Ru decorated carbon foam catalyst in a SpinChem® rotating bed reactor
Topics in Catalysis, 59 (2016) 1165-1177
In quest for the optimal delignification of lignocellulosic biomass using hydrated, SO2 switched DBU MEASIL switchable ionic liquid
Chemical Engineering Journal, 297 (2016) 256–264
Modularized biocatalysis: Immobilization of whole cells for preparative applications in microaqueous organic solvents
ChemCatChem, 8 (2016) 607-614
Deconstruction of Nordic hardwood in switchable ionic liquids and acylation of the dissolved cellulose
Carbohydrate Polymers, 136 (2016) 459-465
Lipase catalyzed regioselective lactamization as a key step in the synthesis of N-Boc (2R)-1,4-oxazepane-2-carboxylic acid
Organic Process Research & Development, 18 (2014) 1116-1119
Enhanced mass transfer upon switchable ionic liquid mediated wood fractionation
Industrial Crops and Products, 55 (2014) 109-115