Results are quite amazing; significantly improved reaction rate, very easy recycling and bullet-proof stability of our enzyme.
- Activated carbon
- Behind the scenes
- Chemical catalysis
- Continuous flow
- Easy handling
- Encapsulated cells
- Fast reaction
- Immiscible liquids
- Immobilized enzymes
- Ion exchange
- Molecular sieve
- One-pot multistep
- Organic molecules
- Palladium on carbon
- Polymeric resin
- Preserved activity
- Quick recycling
- Rapid screening
- Scientific literature
- Seamless scaleup
- Simple cleanup
- Viscous solutions
A performance comparison between a column (fixed bed reactor) and rotating bed reactor (RBR) for de-ionizing 1000 L of tap water. Using best-in-class standard protocols for both technologies, we tested which technology could de-ionize to a desired endpoint conductivity value the quickest. The result show that the RBR is significantly faster, reaching 3.7 times faster a conductivity level of 0.15 µS/cm compared to the column.
4L of Lewatit NM 60 mixed bed resin were packed in a Siliex 1C column and RBR S5, respectively. The output of the column was used as the desired endpoint conductivity value, as it is the less flexible output compared to the RBR. 1000 L of tap water (conducitivity starting point was ca 112 µS/cm, temperature 6-10C) was pumped through the column at a flow rate of 1.8 L/min and after 556 minutes all 1000 L had passed the column. The treated water had an average conductivity value of about 0.15 µS/cm. The same water conditions was used for the RBR where it spun at 300 RPM and reached the same conductivity (0.15 µS/cm) after only 150 minutes.
Accelerated video showing the enhanced adsorption rates of methylene blue onto activated carbon using a rotating bed reactor (RBR) compared to a stirred tank reactor (STR). The RBR decolourized the solution almost twice as fast, did not create any visible fines and required no filtration.
Conditions: Adsorption of methylene blue (100 mg) onto activated carbon (40 mL, 12-40 mesh) placed either in a SpinChem® S311 rotating bed reactor (RBR) or stirred free in solution agitated by a 5 cm impeller, both operated at 800 rpm within a SpinChem® V311 flower-baffled reaction vessel containing 1000 mL water at room temperature. The video is shown at 12x the normal speed. The solution was decolourized after 5 minutes with the RBR, versus close to 10 minutes with the stirred tank reactor (STR). Samples from the RBR set-up required no filtration, but from the STR all samples required filtration through a 45 µm syringe filter for analysis.
The SpinChem® rotating bed reactor (RBR) S100, with a solid phase capacity of 100 L, was used to deionize 7000 L of tap water. The RBR S100 was operating at 160 rpm and filled with 36.5 L of mixed bed ion exchange resin. The results show that the RBR S100 can efficiently process large liquid volumes. As shown by the successful deionization, the performance of the RBR remains high even when it is partially filled, which proves the extreme robustness of the RBR technology.
Municipal tap water (7000 L, Umeå, Sweden) with a conductivity of 113 μS/cm was filled in a rectangular vessel where the rotating bed reactor (RBR) S100 was lowered off center. Lanxess Lewatit NM60 mixed bed resin (36.5 L) for deionizing water was filled in nylon bags (12 pcs, 75 μm mesh size) and the bags were placed evenly distributed in the RBR. The resin bags filled less than half of the RBR volume. The RBR S100 was run at 160 rpm and stopped at 170 minutes when the conductivity had reached 0.083 μS/cm (ca 14 MΩ-cm).
Poster on study of catalyst recycling during esterification and transesterification reactions with immobilized lipases in rotating bed reactors. Data from several laboratories showed that no attrition or grinding occurred and that no filtration was necessary between reaction cycles. The production capacity was estimated to 50 kilograms per gram of catalyst thanks to the high catalyst stability.
Conditions: This study comprised several different laboratories, immobilized enzymes, and conditions for performing esterification and transesterification reactions using a SpinChem® rotating bed reactor (RBR). The details of every reaction are displayed in connection to each figure on the poster. This poster was displayed at Biocat2016 - the 8th international congress on biocatalysis, at Hamburg University of Technology, Germany, August 28th to September 1st, 2016.
Illustrative video showing how a phenolic colourant is deprotonated and extracted from an organic to an aqueous solvent. Using SpinChem® RBR in a flower-baffled reaction vessel created fine emulsion droplets resulting in effective phase-transfer between the two liquids and the solid phase.
Conditions: Red 2,6-dichloroindophenol (about 3 mg) in dichloromethane (70 mL) with water (70 mL) converted to its blue phenolate anion using Purolite A500P (25 mL) in OH form (created by treating Cl form with NaOH) packed into a SpinChem® RBR S221 rotating at 500 rpm in a SpinChem® V211 flower-baffled reaction vessel.
Comparison of rotating bed reactor (RBR) technology and fixed bed reactor (FBR) column during activated carbon decolourization. The more efficient use of the adsorbent with a SpinChem® RBR enabled completion of the process within 40% of the time at the same material amount or allowed reduction to 50% material while still being able to finish the process within the same time as the FBR.
Convenient transfer hydrogenation catalysed by palladium-containing beads was performed using a SpinChem® rotating bed reactor (RBR). The set-up resulted in high product conversions throughout more than 10 consecutive batches without any need for filtration to recycle the catalyst.
Brochure with SpinChem® rotating bed reactors (RBR) – applications, products and technology. Learn from examples how to increase speed and convenience for heterogeneous reactions in laboratory development and production scale. Read about the capabilities and handling benefits with pre-packed cartridges.