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Frequently asked questions
Will my reaction be quicker with SpinChem® RBR?
Yes most likely. All heterogeneous reactions that are mass transfer limited will be faster due to the more efficient convective transport of reaction solution to and from the solid phase packed into SpinChem® RBR. Depending on the reaction this may result in shorter process time, higher yield or less reagent consumption.
Can I perform multistep reactions or one-pot synthesis with SpinChem® RBR?
Yes. You can perform multistep reactions in sequence or in parallel. The SpinChem® RBR is equipped with several compartments which could hold different solid phases at the same time. Imagine using a catalyst and a scavenger simultaneously in a combined one-pot synthesis and cleaning process.
Is it easy to include a SpinChem® RBR in my existing equipment?
Yes it is very easy. Just replace your traditional stirrer with a SpinChem® RBR and you are done.
How often do I need to replace the filters in my SpinChem® RBR?
Frequently. Since this is the only barrier keeping your particles within the RBR, the filters should be replaced at any sign of wear or poor sealing against the edges.
How can I process large volumes with the SpinChem® RBR?
In several ways. You can use a larger RBR, or connect a smaller RBR to an already excising tank, or run repeated cycles with an automated semi-continuous setup. The best choice depends on your process and previously installed equipment.
Can I use SpinChem® RBR with probes for online monitoring?
Yes certainly. Readings from probes in the reaction vessel for measuring parameters such as UV, NIR, pH, etc. often experience less disturbance since the solid phase particles are contained within the SpinChem® RBR instead of swirling pass the probes.
Can I use SpinChem® RBR with any type of reaction vessel?
Yes, but performance will be significantly better in baffled reaction vessels. Maximum mass transfer and minimum vortex formation will be achieved when the SpinChem® RBR is used in the SpinChem® flower-baffled reaction vessels.
Is it easy to recycle my expensive catalyst with SpinChem® RBR?
Yes very easy. Recycling is accomplished by removing the SpinChem® RBR from the reaction vessel and washing it by rotating it in a suitable solvent. The lack of filtration steps will minimize mechanical wear on and loss of particles and maintain activity for a longer time, especially for more fragile materials.
Is it easy to clean my reaction vessel post synthesis with SpinChem® RBR?
Yes. Since there is no solid phase in solution no particles will stick to vessel walls or in drain valves. This can extend the lifetime of your reaction vessel equipment and avoid leaking problems.
Do I need to filtrate my reaction solution after using SpinChem® RBR?
No not likely. Because the solid phase is contained within the SpinChem® RBR there will be no grinding of the solid phase and thus neither any particles nor fines to remove afterwards.
Is SpinChem® RBR suitable if my solvents are immiscible?
Yes. Thanks to the very efficient mixing and mass transfer with SpinChem® RBR there are possibilities to use reaction solutions containing different reagents in immiscible solvents.
Can SpinChem® RBR handle solvents with high viscosity?
Yes. The enhanced mass transfer with SpinChem® RBR compared to traditional stirred tank reactors (STR) is especially powerful with viscous liquids where diffusion is further limited. Optimum performance of the SpinChem® RBR in viscous liquids might require operation at a higher rotational speed.
Can I use SpinChem® RBR for reactions that require oxygen supply?
Yes. The SpinChem® RBR is very efficient in transporting also dissolved gasses to the solid phase and typically provides an oxygen supply that is vastly superior to packed bed reactors (PBR) and better or comparable to stirred tank reactors (STR).
What type of solid phase can I use with SpinChem® RBR?
Any type. As long as the particle size is sufficiently large to be retained by the filter, the SpinChem® RBR is suitable for any type of solid phase, from hard ceramic and glass to soft materials like polymer beads and alginate particles. This encompass a range of functionalities, including ion exchangers, activated carbon, metal scavengers, plain and modified silica, immobilized enzymes, and encapsulated cells.
My solid phase is soft and fragile. Is SpinChem® RBR suitable anyway?
Yes indeed. The protected compartment within the SpinChem® RBR is particularly beneficial for soft or fragile particles, including beads of alginate, gelatin, superporous agarose and polyvinyl alcohol to name a few.
Can I use SpinChem® RBR with whole cells?
Yes, but only if you encapsulate the cells. The size of cells is typically too small for the SpinChem® RBR filer (104 µm), but by encapsulating them within particles such as alginate the particle size will be sufficient to contain them within the SpinChem® RBR.
Can I use SpinChem® RBR if my particle size is 110 µm?
Maybe. The open mesh of the filter in SpinChem® RBR is 104 µm. If your solid material has a very broad particle size distribution a considerable fraction of the particles are smaller than the nominal size and will pass the filter.
Can I pack any size of powder into SpinChem® RBR?
No. The particle size needs to be larger than the 104 µm open mesh of the filter or else the particles will escape from the packed bed. If your solid phase visually appears as a homogenous powder rather than individual particles the particle size is likely smaller than 50 µm.
What rotational speed should I use with SpinChem® RBR?
This depends on your SpinChem® RBR, reaction vessel, reaction type and solid phase. Optimum rotational speed is, however, often in the range 300-600 rpm.
What is the power consumption of a SpinChem® RBR?
Low. Compared to traditional impellers the power consumption is similar or lower.
What is the flow rate through a SpinChem® RBR?
Sufficient. Since the reaction liquid passes the solid phase many times, unlike in a packed bed reactor, the flow rate is of little importance to the implementation. It is also very challenging to measure this flow rate accurately.
At what temperatures can I use my SpinChem® RBR?
In a wide range. From below room temperature up to several hundred degrees Celsius provided that your reaction solution still is in a liquid form.