Recent Publications with Rotating Bed Reactors (11/23)

Our newsletter series brings you selected peer-reviewed research in which our rotating bed reactors (RBR) were used for cutting-edge chemistry. This edition features the syntheses of the amphiphatic antioxidant ascorbyl palmitate, the antifungal agent iBoC, and the flavouring substance vanillin in either biocatalytic or chemocatalytic fashion. - Enjoy!

Biocatalytic synthesis of ascorbyl palmitate

Jessica Holtheuer et al. demonstrate an elegant enzymatic route to this ascorbic ester relevant for food, pharmaceutical and cosmetic applications due to its amphipathic and antioxidant nature. For this, they deployed an immobilized lipase and established a biocatalytic esterification in organic media. The authors recognized that the reactions in the SpinChem RBR “showed great potential for large-scale application" and that "yields remained over 80% after four sequential batches".

Source: Jessica Holtheuer, Luigi Tavernini, Claudia Bernal, Oscar Romero, Carminna Ottone, and Lorena Wilson, Molecules, 2023, 28(2), 644.

Chemocatalytic synthesis of isobutyl o-coumarate

Researchers from the Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A. C. in Mexico reported their screening for bio-based antifungal agents from the hydroxycinnamic acid family. Once isobutyl o-coumarate (iBoC) was identified as most potent against Fusarium oxysporum f. sp. lycopersici, the team followed up by establishing a chemocatalytic route to access iBoC on multi gram scale and recommended the "recovery of the catalyst for further reaction cycles" of the RBR.

Source: Doddy Denise Ojeda-Hernández, Ana Daniela Vega-Rodríguez, Ali Asaff-Torres, and Juan Carlos Mateos-Díaz, 3 Biotech, 2023, 13, 13.

Biocatalytic synthesis of vanillin

Vanillin is one of the most widely used flavouring agents and a great target for the upgrading of lignocellulosic biomass. This recent publication analyses the catalytic capabilities of NspEUGO, which is the second member of the eugenol oxidase family. The authors not just provide a detailed enzyme characterization - including kinetics, substrate screening, immobilization - but also delved into investigations of the proper reactor type and operation mode. Have a look and find an exemplary comprehensive work!

Source: Daniel Eggerichs, Kathrin Zilske, and Dirk Tischler, Mol. Catal., 2023, 546, 113277.


Feel free to reach out to us for any publication you would like to see included in future newsletters by us. We are always happy to hear from users of the rotating bed reactor, and to help the community learn more from you findings.

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