Application L1402

Lipase catalyzed regioselective lactamization as a key step in the synthesis of N-Boc (2R)-1,4-oxazepane-2-carboxylic acid

A synthesis of N-Boc (2R)-1,4-oxazepane-2-carboxylic acid was developed in 39% yield over seven steps starting from methyl (2R)-glycidate. The key step was a lipase-catalyzed regioselective lactamization performed using SpinChem® rotating bed reactor that simplified work up and recycling of the enzyme.

Carl-Johan Aurell*, Staffan Karlsson, Fritiof Pontén, and Søren M. Andersen

Keywords: Biotransformation, Immobilized enzymes, Organic molecules, Quick recycling, Scientific literature

Abstract Image

Privacy Policy

This website uses cookies to ensure you get the best experience on our website. If you continue browsing, you agree to the privacy policy.