A synthesis of N-Boc (2R)-1,4-oxazepane-2-carboxylic acid was developed in 39% yield over seven steps starting from methyl (2R)-glycidate. The key step was a lipase-catalyzed regioselective lactamization performed using SpinChem® rotating bed reactor that simplified work up and recycling of the enzyme.
Carl-Johan Aurell*, Staffan Karlsson, Fritiof Pontén, and Søren M. Andersen
Keywords: Biotransformation, Immobilized enzymes, Organic molecules, Quick recycling, Scientific literature
Topics Biocatalysis, Downstream Processing, Scientific Literature
Industries Pharmaceutical and Cosmetics
Products SpinChem® RBR S3
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