Application L1701
A novel hierarchically structured siliceous packing to boost the performance of rotating bed enzymatic reactors

Katarzyna Szymańska, Klaudia Odrozek, Aurelia Zniszczoł, Wojciech Pudło, and Andrzej B. Jarzębski Chem. Eng. J., 2017, 315, pp. 18-24.

Application L1801
Advanced oxidation process for the removal of ibuprofen from aqueous solution: A non-catalytic and catalytic ozonation study in a semi-batch reactor

Soudabeh Saeid, Pasi Tolvanen, Narendra Kumar, Kari Eränen, Janne Peltonen, Markus Peurla, Jyri-Pekka Mikkola, Andreas Franz, and Tapio Salmi Appl. Catal. B, 2018, 230, pp. 77-90.

Application L1704
Biocatalysis engineering: the big picture

Roger A. Sheldon and Pedro C. Pereira Chem. Soc. Rev., 2017, 46(10), pp. 2678-2691.

Application L1604
Catalytic hydrogenation of d-xylose over Ru decorated carbon foam catalyst in a SpinChem® rotating bed reactor

Tung Ngoc Pham, Ajaikumar Samikannu, Anne-Riikka Rautio, Koppany L. Juhasz, Zoltan Konya, Johan Wärnå, Krisztian Kordas, and Jyri-Pekka Mikkola Top. Catal., 2016, 59, pp. 1165-1177.

Application L1702
CFD modeling of flow and ion exchange kinetics in a rotating bed reactor system

Hilde Larsson, Patrick Alexander Schjøtt Andersen, Emil Byström, Krist V. Gernaey, and Ulrich Krühne Ind. Eng. Chem. Res., 2017, 56, 14, pp. 3853-3865.

Application L1601
Deconstruction of Nordic hardwood in switchable ionic liquids and acylation of the dissolved cellulose

Valerie Eta and Jyri-Pekka Mikkola Carbohydr. Polym., 2016, 136, pp. 459-465.

Application L2204
Design of a green chemoenzymatic cascade for scalable synthesis of bio-based styrene alternatives

Philipp Petermeier, Jan Philipp Bittner, Simon Müller, Emil Byström, Selin Kara Green Chemistry, 2022, 24(18), pp. 6889-6899.

Application L1301
Efficient biocatalysis with immobilized enzymes or encapsulated whole cell microorganism by using the SpinChem reactor system

Hendrik Mallin, Jan Muschiol, Emil Byström, and Uwe T. Bornscheuer ChemCatChem, 2013, 5, pp. 3529-3532.

Application L1401
Enhanced mass transfer upon switchable ionic liquid mediated wood fractionation

Valerie Eta, Ikenna Anugwom, Pasi Virtanen, P. Mäki-Arvelaa, and Jyri-Pekka Mikkola Ind. Crops Prod., 2014, 55, pp. 109-115.

Application L1802
Epoxidation of fatty acids and vegetable oils assisted by microwaves catalyzed by a cation exchange resin

Adriana Freites Aguilera, Pasi Tolvanen, Shuyana Heredia, Marta González Muñoz, Tina Samson, Adrien Oger, Antoine Verove, Kari Eränen, Sebastien Leveneur, Jyri-Pekka Mikkola, and Tapio Salmi Ind. Eng. Chem. Res., 2018, 57(11), pp. 3876-3886.

Application L1605
Fibre stress-strain response of high-temperature chemi-thermomechanical pulp treated with switchable ionic liquids

Ran Duan, Bo S. Westerlind, Magnus Norgren, Ikenna Anugwom, Pasi Virtanen, and Jyri-Pekka Mikkola BioRes., 2016, 11(4), pp. 8570-8588.

Application L2213
Impact of critical parameters influencing enzymatic production of structured lipids using response surface methodology with water activity control

Ariana Causevic, Eimantas Gladkauskas, Kim Olofsson, Patrick Adlercreutz, and Carl Grey Biochem. Eng. J., 2022, 187, 108610.

Application L1603
In quest for the optimal delignification of lignocellulosic biomass using hydrated, SO2 switched DBU MEASIL switchable ionic liquid

Ikenna Anugwoma, Luis Rujana, Johan Wärnå, Mattias Hedenström, and Jyri-Pekka Mikkola Chem. Eng. J., 2016, 297, pp. 256-264.

Application L1903
L-Asparaginase production in rotating bed reactor from Rhizopus microsporus IBBL-2 using immobilized Ca-alginate beads

Anup Ashok and Santhosh Kumar Devarai 3 Biotech, 2019, 9(9), 349.

Application L1402
Lipase catalyzed regioselective lactamization as a key step in the synthesis of N-Boc (2R)-1,4-oxazepane-2-carboxylic acid

Carl-Johan Aurell, Staffan Karlsson, Fritiof Pontén, and Søren M. Andersen Org. Process Res. Dev., 2014, 18(9), pp. 1116-1119.

Application L1602
Modularized biocatalysis: Immobilization of whole cells for preparative applications in microaqueous organic solvents

Jochen Wachtmeister, Philip Mennicken, Andreas Hunold, and Dörte Rother ChemCatChem, 2016, 8, pp. 607-614.

Application L2117
Multi‐enzyme cascade reaction in a miniplant two‐phase‐system: Model validation and mathematical optimization

Jens Johannsen, Francesca Meyer, Claudia Engelmann, Andreas Liese, Georg Fieg, Paul Bubenheim, and Thomas Waluga AIChE J., 2021, 67(4), e17158.

Application L2102
New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy

An interesting paper where the authors mentions ”A further refinement, the rotating bed reactor developed by SpinChem... This technology combines the benefits of an STR and a packed bed and has been scaled up successfully to more than 100 litres scale.” Key learnings from the paper (1) The advantages and limitations of immobilised enzymes in industrial applications (2) The different technical and regulatory requirements using immobilised enzymes (3) The different enzyme immobilisation methods (4) The different reactor technologies for immobilised enzymes and biocatalysis in general (5) Recent advances in enzyme immobilisation for better production economy

Application L2110
Process design of a continuous biotransformation with in situ product removal by cloud point extraction

In biotransformations, obstacles commonly encountered are product inhibition, product toxicity, and reaction equilibria that prevents complete conversion. Enzyme engineering has made tremendous progress in alleviating these problems. The concept of in situ product removal (ISPR) may still be an attractive alternative or complement. The authors have demonstrated concurrent enzymatic reaction and ISPR, referred to as 'extractive biocatalysis'. For the ISPR, the authors evaluated the use of aqueous micellar two-phase systems (ATPMS) as an extraction medium. For the model reaction, Penicillin G hydrolysis by CalB lipase, the demonstrated process was thus a continuous, heterogeneous extractive biocatalysis with cloud point extraction. An RBR was used during the process development work to determine the Michaelis-Menten kinetics of the CalB immobilized in gel coatings on column packing material. Also, the particles were easily re-used in stability experiments.

Application L2112
Production of hydroxytyrosol rich extract from Olea europaea leaf with enhanced biological activity using immobilized enzyme reactors

Alexandra V. Chatzikonstantinou, Αrchontoula Giannakopoulou, Stamatia Spyrou, Yannis V. Simos, Vassiliki G. Kontogianni, Dimitrios Peschos, Petros Katapodis, Angeliki C. Polydera, and Haralambos Stamatis Environ. Sci. Pollut. Res., 2022, 29, pp. 29624-29637.

Application L2115
Production of recombinant choline oxidase and its application in betaine production

S. Lokesha, Y. S. Ravi Kumar, P. S. Sujan Ganapathy, Prashant Gaur, and H. M. Arjun 3 Biotech, 2021, 11, 410.

Application L1901
Progress on the pre-treatment of lignocellulosic biomass employing ionic liquids

Pobitra Halder, Sazal Kundu, Savankumar Patel, Adi Setiawan, Rob Atkin, Rajarathinam Parthasarthy, Jorge Paz-Ferreiro, Aravind Surapaneni, and Kalpit Shah Renewable Sustainable Energy Rev., 2019, 105, pp. 268-292.

Application L2119
Pseudomonas taiwanensis biofilms for continuous conversion of cyclohexanone in drip flow and rotating bed reactors

Ingeborg Heuschkel, Selina Hanisch, Daniel C. Volke, Erik Löfgren, Anna Hoschek, Pablo I. Nikel, Rohan Karande, and Katja Bühler Eng. Life Sci., 2021, 21(3-4), pp. 258-269.

Application L1703
Reaction engineering of biocatalytic (S)-naproxen synthesis integrating in-line process monitoring by Raman spectroscopy

M. Aßmann, A. Stöbener, C. Mügge, S. K. Gaßmeyer, L. Hilterhaus, R. Kourist, A. Liese, and S. Kara React. Chem. Eng., 2017, 2(4), pp. 531-540.

Application L1606
Recent advances in whole cell biocatalysis techniques bridging from investigative to industrial scale

Jochen Wachtmeister and Dörte Rother Curr. Opin. Biotechnol., 2016, 42, pp. 169-177.

Application L1705
Role of biocatalysis in sustainable chemistry

Roger A. Sheldon and John M. Woodley Chem. Rev., 2018, 118(2), pp. 801-838.

Application L2005
Solvent and Rotating Bed Reactor Extraction with One- and Two-Phase Solvents Applied to Bilberries (Vaccinium myrtillus) for Isolating Valuable Antioxidants

Correlation data between extracted anthocyanidins/ anthocyanins vs time, temperature, and ethanol concentration was collected and analyzed. RBR extraction was deemed advantageous, in the authors’ own words: “The RBR was better than traditional extraction and 16 min sufficed.” Bilberry press cake is the major by-product from the production of bilberry juice. To valorize the press cake, the authors describe their work to extract antioxidant antocyanidins/ antocyanins from the cake. Different solvent compositions were compared as well as traditional extraction vs extraction by use of RBR. The methods used were as follows: “To summarize, the compared extraction methods were as follows: 1. Traditional extraction using different concentrations of ethanol dissolved in water, different masses of material, and different temperatures. 2. RBR extraction using different concentrations of ethanol dissolved in water, different masses, and temperatures. 3. RBR extraction using two-phase system, method 3 only mass and temperature were changed. 4. RBR extraction using two-phase system method 4, only mass and temperature were changed.”  

Application L2001
Using Spinchem Rotating Bed Reactor Technology for Immobilized Enzymatic Reactions: A Case Study

Subhash Pithani, Staffan Karlsson, Hans Emtenäs, and Christopher T. Öberg Org. Process Des. Dev., 2019, 23(9), pp. 1926-1931.

Application L1706
Whole-cell cascade biotransformations for one-pot multistep organic synthesis

Shuke Wu and Zhi Li ChemCatChem, 2018, 10(10), pp. 2164-2178.

Application L2202
Asymmetric Hydrogenation of C = C Bonds in a SpinChem Reactor by Immobilized Old Yellow Enzyme and Glucose Dehydrogenase

Teng Ma, Weixi Kong, Yunting Liu, Hao Zhao, Yaping Ouyang, Jing Gao, Liya Zhou, and Yanjun Jiang Appl. Biochem. Biotechnol., 2022, 194, pp. 4999–5016.

Application L2207
Lipase catalyzed green epoxidation of oleic acid using ultrasound as a process intensification method

Adriana Freites Aguilera, Pontus Lindroos, Jani Rahkila, Mark Martinez Klimov, Pasi Tolvanen, and Tapio Salmi Chem. Eng. Process. Process Intensif., 2022, 174, 108882.

Application L2203
Peroxygenase-Driven Ethylbenzene Hydroxylation in a Rotating Bed Reactor

Markus Hobisch, Piera De Santis, Simona Serban, Alessandra Basso, Emil Byström, and Selin Kara Org. Process Res. Dev., 2022, 26(9), pp. 2761-2765.

Application L2301
Comparison of Four Immobilization Methods for Different Transaminases

Tobias Heinks, Nicolai Montua, Michelle Teune, Jan Liedtke, Matthias Höhne, Uwe T. Bornscheuer, and Gabriele Fischer von Mollard Catalysts, 2023, 13(2), 300.

Application L2302
Fatty Acid Epoxidation on Enzymes: Experimental Study and Modeling of Batch and Semibatch Operation

Wilhelm Wikström, Adriana Freites Aguilera, Pasi Tolvanen, Robert Lassfolk, Ananias Medina, Kari Eränen, and Tapio Salmi Ind. Eng. Chem. Res., 2023, 62(23), pp. 9169-9187.

Application L2303
Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib

Christopher K. Prier, Karla Camacho Soto, Jacob H. Forstater, Nadine Kuhl, Jeffrey T. Kuethe, Wai Ling Cheung-Lee, Michael J. Di Maso, Claire M. Eberle, Shane T. Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin M. Maloney, Amanda Makarewicz, Jonathan P. McMullen, Jeffrey C. Moore, Grant S. Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David A. Thaisrivongs, Deeptak Verma, Adeya Wyatt, and Daniel Zewge ACS Catal., 2023, 13(12), pp. 7707-7714.

Application L2120
Rotating bed reactor packed with heterofunctional structured silica-supported lipase. Developing an effective system for the organic solvent and aqueous phase reactions

Daria Kowalczykiewicz, Katarzyna Szymańska, Danuta Gillner, and Andrzej B. Jarzębsk Microporous Mesoporous Mater., 2021, 312, 110789.

Application 2116
Prilezhaev epoxidation of oleic acid in the presence and absence of ultrasound irradiation

Adriana Freites Aguilera, Roosa Hämäläinen, Kari Eränen, Pasi Tolvanen, and Tapio Salmi J. Chem. Technol. Biotechnol., 2021, 96(7), pp. 1874-1881.

Application L2002
Determination of kinetics and equilibria of heterogeneously catalyzed gas-phase reactions in gradientless autoclave reactors by using the total pressure method: Methanol synthesis

Tapio Salmi, Kari Eränen, Pasi Tolvanen, J.-P. Mikkola, and Vincenzo Russo Chem. Eng. Sci., 2020, 215, 115393.

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