Application L2003 Cover of Journal Current Opinion in Green and Sustainable Chemistry, white text on green background with a grassy hill and a tree

Pharmaceutical industry perspectives on flow chemocatalysis and biocatalysis

Laura Leemans Martin, Theo Peschke, Francesco Venturoni, and Serena Mostarda

Curr. Opin. Green Sustainable Chem., 2020, 25, 100350.

“In response to a growing demand for more sustainable and cost-effective synthetic processes, the pharmaceutical industry is increasingly relying on continuous manufacturing as a valuable alternative to conventional batch processing. Particularly, flow processing may enable process intensification of chemocatalytic and biocatalytic transformations, both being of strategic importance on the design and production of active pharmaceutical ingredients. This review outlines the current status of flow chemocatalysis and biocatalysis within the pharmaceutical landscape. Furthermore, the trends and challenges that these technologies face are highlighted, based on recently disclosed applications from industry and innovative solutions from academia.”



  • “Nevertheless, long-term operational stability of immobilized biocatalysts may also be improved by advances in reactor engineering, which enable reproducibility and reusability at scale [45,46].”
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