Application L2304 Cover of React. Chem. Eng. Journal showing a man in front of an array of tubular flow reactors and a hand holding an illustration of a cell

Boosting the catalytic performance of a marine yeast in a SpinChem® reactor for the synthesis of perillyl alcohol

Silvia Donzella, Concetta Compagno, Francesco Molinari, Francesca Paradisi, and Martina Letizia

React. Chem. Eng., 2023, 8(12), pp. 2963-2966.

"A sustainable approach for the reduction of perillaldehyde to perillyl alcohol (POH) through alginate immobilized yeast cell beads has been here developed. The process was optimized in small-scale batch reactions and then scaled up in a rotating bed reactor (SpinChem®), enhancing productivity while reducing catalyst loading thanks to better mass transfer and catalyst/substrate interaction (i.e., 90% molar conversion, 8 hours). The biocatalyst biomass was also grown on waste material (molasses) and cultivated using seawater to minimize the environmental impact. By harnessing the potential of immobilized yeast cells in a rotating reactor and utilizing eco-friendly resources, this study exemplifies a sustainable biocatalytic approach that can be extended to other natural terpenes. The incorporation of waste materials and seawater into the process showcases the commitment to increase the sustainability of chemical reactions and aligns with the principles of circular economy."



  • “The SpinChem® reactor is ideal to be used with cells immobilized in hydrogel beads as catalysts. Using this system, more than 90% of molar conversion was reached after 8 hours in a working volume of 200 mL”
  • “In summary, this study represents a successful proof of concept to demonstrate the viability and potential applicability of immobilized yeast cells for the modification of natural terpenes through SpinChem® technology.”

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