Application L2117

Multi‐enzyme cascade reaction in a miniplant two‐phase‐system : Model validation and mathematical optimization

In the American Institute of Chemical Engineers, AIChE Journal, the authors of this paper highlights the use of Rotating Bed Reactor (RBR) with two different immobilized enzymes at the same time in a cascade reaction.

In the flow chart above of the miniplant consisting of a continuously stirred tank reactor (CSTR) equipped with an RBR (highlighted in orange) (a), a buffer tank (b), an extractive centrifuge (c) and a fixed bed reactor (d) 

In the reaction scheme the complete multi-enzyme cascade is shown with the two enzymes placed in the RBR is highlighted. Multi-enzyme cascade reaction sequence for the production of cinnamyl cinnamate from cinnamyl aldehyde with integrated co factor regeneration and in situ intermediate extraction in a two-phase system

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Details

Jens Johannsen, Francesca Meyer, Claudia Engelmann, Andreas Liese, Georg Fieg, Paul Bubenheim, Thomas Waluga AIChE Journal Volume67, Issue4, April 2021, e17158

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